I apologize for my late response to these posts. I was on a long trip overseas. Regardless, I’d like to put the record straight regarding this topic. (Read my first creatine post here)
The point is: AMPK was found to be negatively regulated by the cellular ratio of phosphocreatine/creatine. The higher this ratio is, the more inactivated AMPK becomes. Hence, the higher the level of creatine phosphate is (all creatine supplements increase cellular levels of creatine phosphate), the more inhibited AMPK will be.
Creatine is indeed one of the most researched supplements with proven record of increasing muscle mass and strength gain; it is also one of the biggest money makers in the sport nutrition industry. Nevertheless, creatine is a synthetic substance with a drug-like impact involving potential side effects and risks.
Criticizing creatine might be politically incorrect these days, but I believe that that’s exactly what makes this issue particularly important – expressing true opinion about products which are treated as the “sacred cows” by mainstream fitness and the industry. I’ve always been expressing my opinion regardless to how popular they are.
Fifteen years ago, my concept of intermittent fasting and skipping meals were considered dietary heresy. Today IF is one of the most popular approaches to dieting and every diet guru tries to jump on that wagon.
There is an evolutionary process to controversial ideas. Opinions that were initially raising great resistance and anger have been proven later as factually true and thus respected accordingly. I was ahead of time when I came with the concept of intermittent fasting as a practical diet and perhaps I’m ahead of time with this issue now.
Final Note: Creatine manufacturers insist that creatine is safe. But how safe is it? The industry tries to “wash out” the evidence of side effects. I remember how aspartame was considered “safe” twenty years ago, when it was used as a popular sweetener in all sorts of sport nutrition products. I also remember how fructose was popularized as a safe sugar that does not raise insulin. It is now known that none of these are safe. Would creatine be a similar case? Only time will tell…
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